Effect of Bisphenol A on Nephrotoxicity in Rats and The protective Role of Giloy and Echinacea Against This Effect

The BPA present in thepolycarbonate plastics and epoxy resins moves from the packaging material to thedairy products eventually and caused toxicity .So that; this study aimed to investigatethe potential protective effect of Giloy (Tinospora cordifolia) (T.cordifolia) and Echinacea (Echinacea purpurea ;E. purpurea), on nephrotoxicity inexperimental rats. Thirty six male albino rats (50±10 g) were randomly assigned to 6equal groups (6 rats each), the first kept as as a negative control group (-v) controlreceived basal diet throughout the experimental period . While second was positivecontrol group (+v) control which treated orally with BPA (25 mg/kg/day) dissolved inolive oil, to induce nephrotoxicity once daily, for 6 weeks while the four othersgroups fed on basal diet and treated orally with BPA (25 mg/kg/day) and ethanolicextracts of T. cordifolia (200, 400 mg/kg/day) and E. purpurea (200, 400mg/kg/day)for 6 weeks ( as a protective experiment ) . At the end of experimental period,biological evaluation, serum antioxidant enzymes, kidney function, Na, K wereevaluated and MDA were estimated. Also histological changes of kidney tissues wereexamined. The obtained results concluded that supplemented diets with plant materials(extract of T. cordifolia and E. purpurea) improved antioxidant enzymes status,kidney function, Na, K and MDA. The best results found in high doses of T.cordifolia and E. purpurea followed by low doses of T. cordifolia and E. purpurea.So, these plants could be used for improves nephrotoxicity and may be other kidneyfunctions.