Age-related differences in functional and post-operative outcomes in spinal anesthesia for open appendectomy with Dexmedetomidine

Background: Dexmedetomidine , a selective α2 adrenergic agonist, preserves neurological function and mitigates neuronal damage. Aim: This study examined age-related variations in the efficacy and postoperative outcomes of DEX in patients undergoing open appendectomy under spinal anesthesia. Patients and Methods: A prospective observational study was conducted on 74 patients receiving DEX perioperatively. Participants were stratified into four age groups: <20 years (n=12), 20-30 years (n=43), 30-40 years (n=8), and >40 years (n=11). Results: Intraoperative adverse events (e.g., bradycardia, hypotension) and postoperative outcomes (analgesia duration, VAS scores, Bromage score) showed no significant age-related differences. However, older patients exhibited higher ASA scores (P<0.001), indicating greater comorbidities. VAS scores at 1-hour post-surgery differed significantly (P=0.017), with younger patients reporting lower pain. Conclusion: While most outcomes were consistent across age groups, the disparity in ASA classification underscores the impact of aging-related comorbidities on perioperative management. The stability of intraoperative and postoperative parameters, including pain and sensory recovery, suggests Dexmeditomidine reliability as a therapeutic agent across diverse ages. Keywords: Dexmeditomidine, ASA classification, Bromage score.