Roles of GDF9 and BMP15 in equine follicular development: in vivo content and in vitro effects of IGF1 and cortisol on granulosa cells
Together, our results show GDF9 localization and expression in the equine ovary and a temporal relationship with steroidogenesis and cell proliferation within the surrounding granulosa cells. Moreover, results of the in vitro study suggest a supporting role of cortisol during follicle maturation. Our study sheds light on possible mechanisms for the regulation of ovarian function in horses using GDF9.
Authors
- Mariusz P. Kowalewski (ORCID: https://orcid.org/0000-0002-4565-7714)
- H. Bollwein (ORCID: https://orcid.org/0000-0003-1982-5101)
- Kosar Abbasi Samie
- G.D.A. Gastal (ORCID: https://orcid.org/0000-0002-5317-2207)
- Gerhard Schüler (ORCID: https://orcid.org/0000-0002-9412-3743)
- Dragos Scarlet (ORCID: https://orcid.org/0000-0002-9599-0830)
Institutions
- Justus-Liebig-Universität Gießen (DE)
- University of Zurich (CH)
- Center for Pediatric Endocrinology Zurich (CH)
- Instituto Nacional de Investigación Agropecuaria (UY)
- Lindenhofspital (CH)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1186/s12917-025-04744-6
- Citations
- 3
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Eidgenössische Technische Hochschule Zürich
- Universität Zürich