Two New Diketopiperazine Alkaloids from a Deep-soil Derived Fungus Penicillium simplicissimum GZWMJZ-1612

Two new diketopiperazine alkaloids, namely simplicamides A (1) and B (2), were isolated from the deep-soil derived fungus Penicillium simplicissimum GZWMJZ-1612.The structures of these two compounds were determined by NMR, HRESIMS, ECD calculation, and Marfey's method.Compound 1 exhibited potent antioxidant capacity of ORAC and DPPH scavenging ability.Compound 2 displayed significant ORAC scavenging ability and -glucosidase inhibitory activity.