Electrochemically Promoted Amination of Pyrido[2,3‐d]pyrimidin‐7‐ones: Efficient Synthesis of Palbociclib Derivatives
The pyrido[2,3‐ d ]‐pyrimidin‐7‐one template is a crucial molecular fragment in antineoplastic drug palbociclib. Considering the importance of pyrido[2,3‐ d ]‐pyrimidin‐7‐one template, herein, a simple and environmentally friendly electrocatalytic amination of pyrido[2,3‐ d ]pyrimidin‐7‐ones is reported with N,N ‐dialkyl formamides as the amine source and NaBr as the electrolyte. This straightforward and operationally simple protocol opens a green and efficient strategy for the synthesis of palbociclib derivatives in moderate to good yields.
Authors
- Qing Zhu (ORCID: https://orcid.org/0000-0002-0761-9434)
- Zhang Li-xi (ORCID: https://orcid.org/0000-0002-3699-1585)
- Chao Shen (ORCID: https://orcid.org/0000-0001-8826-5879)
- Dong Wang (ORCID: https://orcid.org/0000-0002-2435-9179)
- Jiabin Shen (ORCID: https://orcid.org/0009-0009-0908-8946)
- Pengfei Zhang (ORCID: https://orcid.org/0000-0001-9859-0237)
Institutions
- Hangzhou Normal University (CN)
- Zhejiang Shuren University (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1002/ejoc.202500259
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province