PI3K signaling pathway inhibitor affects myeloma cells in a culture-dependent manner
LY294002 affected U266 cell viability and cell cycle in a dose-dependent manner in 2D mono-cultures. However, its impact varied in 3D cultures. Treatment of MNCs showed varied responses based on individuals and culture conditions, underscoring the need for more similar tumor microenvironment (TME) recapitulation for drug screening.
Authors
- Sadaf Vahdat (ORCID: https://orcid.org/0000-0002-0223-9838)
- Saeid Kaviani (ORCID: https://orcid.org/0000-0003-2213-8142)
- Mehrnaz Janfada (ORCID: https://orcid.org/0009-0000-9139-6167)
Institutions
- Tarbiat Modares University (IR)
Publication Details
- Journal
- Advanced Pharmaceutical Bulletin
- Published
- 2025-04-24
- DOI
- https://doi.org/10.34172/apb.025.42774
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Iran National Science Foundation
- Tarbiat Modares University