Hypertension in obstructive sleep apnea: the hidden role of renin–angiotensin–aldosterone system dysregulation
This is the first study from Southeast Asia evaluating the impact of RAAS on hypertension severity in OSA patients. Findings suggest that hypertensive individuals with OSA exhibit greater RAAS dysregulation, highlighting the role of aldosterone in the development of hypertension and its severity in OSA. This also underscores the need for targeted management strategies particularly in tropical regions with a rising prevalence of metabolic disorders.
Authors
- Siow Phing Tay
- Anselm Ting Su (ORCID: https://orcid.org/0000-0001-8153-3244)
- Bin Tang (ORCID: https://orcid.org/0000-0001-6096-0837)
- Norlela Sukor (ORCID: https://orcid.org/0000-0002-5434-2087)
- Elena Aisha Azizan
- Ai Jiun Koa
- Mei Ching Yong
- Asri Said (ORCID: https://orcid.org/0000-0003-3008-5204)
- Chee-Shee Chai (ORCID: https://orcid.org/0000-0002-4277-6152)
- Florence Hui Sieng Tan
- N Malik
Institutions
- Hospital Kuala Lumpur (MY)
- Sarawak General Hospital (MY)
- University Kebangsaan Malaysia Medical Centre (MY)
- Universiti Malaysia Sarawak (MY)
- National University of Malaysia (MY)
Publication Details
- Journal
- Tropical Medicine and Health
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s41182-025-00742-4
- Citations
- 4
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Ministry of Higher Education, Malaysia
- Universiti Kebangsaan Malaysia