Low-dose apixaban in HeartMate 3 LVAD patients, interim analysis of the ApixiVAD trial, a randomized controlled study
These interim results were obtained after the end of recruitment but before all patients reached the full follow-up duration. The rates of bleeding observed in the apixaban group were below those reported in large international studies without any increase in thrombosis, suggesting that apixaban 2.5 mg twice daily may offer an effective balance between bleeding risk and anticoagulation efficacy. These findings should be interpreted as preliminary and hypothesis-generating.
Authors
- David Reineke (ORCID: https://orcid.org/0000-0002-3317-6219)
- Eleni Xourgia (ORCID: https://orcid.org/0000-0001-5766-3209)
- K. Muthiah (ORCID: https://orcid.org/0000-0002-3293-7119)
- Sanjay Chavali
- Ricardo Deveza
- Kaitlyn Lam (ORCID: https://orcid.org/0000-0001-8369-229X)
- Lukas Capék (ORCID: https://orcid.org/0000-0002-6190-1473)
- Bruno Schnegg (ORCID: https://orcid.org/0000-0002-7660-6258)
- Maryam Pavlicek‐Bahlo
- Phillip Lo
- Jolie Bruno (ORCID: https://orcid.org/0000-0002-6356-2284)
- Sumita Barua (ORCID: https://orcid.org/0000-0001-9091-6773)
- Alexandra Neagoe
- Matthias Siepe (ORCID: https://orcid.org/0000-0003-3305-9343)
- Kathrin Zürcher (ORCID: https://orcid.org/0000-0002-7915-3194)
- Peter S. Macdonald (ORCID: https://orcid.org/0000-0001-5378-2825)
- Chris Hayward (ORCID: https://orcid.org/0000-0003-4036-1890)
- Lukas Hunziker (ORCID: https://orcid.org/0000-0003-0081-8518)
- Michele Martinelli (ORCID: https://orcid.org/0000-0002-2585-3005)
Institutions
- University of Bern (CH)
- Victor Chang Cardiac Research Institute (AU)
- Fiona Stanley Hospital (AU)
- University Hospital of Bern (CH)
- St Vincent's Hospital Sydney (AU)
- St Vincent's Clinic (AU)
Publication Details
- Journal
- The Journal of Heart and Lung Transplantation
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1016/j.healun.2025.04.012
- Citations
- 11
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 7.42