Restorative potential of Phoenix dactylifera fruit and extract against oxidative stress mediated cardiac dysfunction in rodent experimental modeling

The study evaluates the cardioprotective effects of date fruit ( Phoenix dactylifera ) and its extract against oxidative stress-induced cardiac dysfunction in a rat model. Date extract was more effective than whole fruit in reducing serum cardiac stress biomarkers. AST levels decreased by 19 % with the extract and 14.47 % with whole fruit, while CK declined by 3.80 % and 2.34 %, respectively. LDH levels dropped by 22.51 % with extract and 16.01 % with fruit, and CK-MB improved by 18.02 % in the extract-treated group. Antioxidant enzyme activity increased significantly, with SOD rising by 38.34 % and CAT by 35.71 %, while lipid peroxidation (MDA) decreased by 25.67 %. Histopathological analysis showed better myocardial structure with less congestion, necrosis, and inflammation, especially in the extract group. Hematological parameters remained unchanged. These findings indicate that date fruit and its extract may help mitigate oxidative stress-induced cardiac dysfunction. Further research is required to understand their molecular mechanisms and clinical potential. • Date fruit and extract protect against oxidative stress-induced cardiac dysfunction. • Date extract reduces cardiac stress biomarkers more effectively than whole fruit. • Histopathology shows reduced congestion, necrosis, and inflammation. • Date fruit and extract offer potential for cardiovascular protection.