Aberrant overexpression of m6A writer and reader genes in pediatric B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Despite the collective dysregulation of the m6A machinery, the writers and readers appear to have a more dominant phenotype, as evidenced by the significantly elevated m6A% levels. This is the first study to analyze and establish the role of m6A machinery gene expression and its correlation with survival outcomes in a large group of B-ALL patients. These findings could aid in the development of new therapeutics targeting the m6A machinery and help predict relapse in pediatric B-ALL patients.
Authors
- Sameer Bakhshi (ORCID: https://orcid.org/0000-0001-9367-4407)
- Karthikeyan Pethusamy (ORCID: https://orcid.org/0000-0001-7155-2257)
- Shuvadeep Ganguly (ORCID: https://orcid.org/0000-0002-7296-6088)
- Anita Chopra (ORCID: https://orcid.org/0000-0002-0238-8702)
- Parthaprasad Chattopadhyay (ORCID: https://orcid.org/0000-0002-0108-2920)
- Sumedha Saluja (ORCID: https://orcid.org/0000-0002-9041-4893)
- Subhradip Karmakar (ORCID: https://orcid.org/0000-0002-4757-8729)
- Gunjan Sharma (ORCID: https://orcid.org/0000-0003-3110-9239)
- Archna Singh (ORCID: https://orcid.org/0000-0001-6487-6632)
- Jayanth Kumar Palanichamy (ORCID: https://orcid.org/0000-0002-3903-7252)
- Ayushi Jain (ORCID: https://orcid.org/0000-0001-9515-4034)
- Jay Singh (ORCID: https://orcid.org/0000-0003-4896-977X)
- Shilpi Chaudhary (ORCID: https://orcid.org/0000-0002-4273-8279)
Institutions
- DR. B.R.A. Institute Rotary Cancer Hospital (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1016/j.tranon.2025.102403
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61