Increased intestinal mucosal permeability and metabolic endotoxemia predict the risk of cardiovascular mortality
The results support metabolic endotoxemia as a contributing pathogenetic factor in atherosclerotic cardiovascular disease with an adverse outcome. Of the surrogate biomarkers studied, zonulin was the most robust predictor of mortality in CAD. Levels of zonulin, LBP, and I-FABP remained relatively stable in individuals over the 15-year follow up, suggesting a potential role for them as biomarkers for ASCVD risk.
Authors
- Katariina Nurmi (ORCID: https://orcid.org/0000-0001-5406-5334)
- Timo Strandberg (ORCID: https://orcid.org/0000-0001-6299-925X)
- J. Parantainen (ORCID: https://orcid.org/0000-0002-6791-198X)
- Kari K. Eklund (ORCID: https://orcid.org/0000-0002-5870-4663)
- N. Mars
- Gonçalo Barreto (ORCID: https://orcid.org/0000-0003-4444-9208)
Institutions
- University of Helsinki (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Institute for Molecular Medicine Finland (FI)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.119220
- Citations
- 4
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22