IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury by regulating neuronal ferroptosis and microglial polarization
IGF2BP1 serves as a critical regulator of cerebral I/R injury by exacerbating neuronal ferroptosis and sustaining detrimental microglial activation. These findings nominate IGF2BP1 inhibition as a promising strategy for ischemic stroke intervention.
Authors
- Youjun Li (ORCID: https://orcid.org/0009-0002-3506-7259)
- Ying Xia (ORCID: https://orcid.org/0000-0001-6706-0911)
- Junwen Jiang
- Yi Zhuo (ORCID: https://orcid.org/0000-0003-2743-9606)
- You Li (ORCID: https://orcid.org/0000-0002-9611-1877)
- Jiameng Li (ORCID: https://orcid.org/0000-0002-3652-8849)
- Zhengtao Yu (ORCID: https://orcid.org/0000-0003-0996-2284)
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Haikou City People's Hospital (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1016/j.bbadis.2025.167877
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 6.55