Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data

Biologic initiation in patients with SA led to substantial reduction in TOCS exposure, particularly in the first year. Future analyses will explore the impact on OCS-related adverse health events.

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Publication Details

Journal
The Journal of Allergy and Clinical Immunology In Practice
Published
2025-04-26
DOI
https://doi.org/10.1016/j.jaip.2025.04.032
Citations
11
Primary Topic
Asthma and respiratory diseases
Type
article
Field-Weighted Citation Impact
12.81

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article

Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data

Lakmini Bulathsinhala, Piotr Kuna, Breda Cushen, Matthew Peters et al.
11 citations
The Journal of Allergy and Clinical Immunology In Practice
Asthma and respiratory diseases
12.81
article

Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data

Lakmini Bulathsinhala, Piotr Kuna, Breda Cushen, Matthew Peters, Guy Brusselle, Riyad Al‐Lehebi, Martín Sívori, Mariko Siyue Koh, Tatsuya Nagano, Andriana Ι. Papaioannou, Liam Gabriel Heaney, Fernando Saldarini, Mohit Bhutani, Konstantinos Exarchos, Benjamin Emmanuel, Wenjia Chen, Carlos Andrés Celis Preciado, Ruth Murray, Njira Lucia Lugogo, Athena Gogali, Sinthia Bosnic‐Anticevich, Chau‐Chyun Sheu, Kirsty Fletton, Andrew Menzies‐Gow, Florence Schleich, Mohsen Sadatsafavi, Hao‐Chien Wang, Trung N. Tran, Cathy Emmas, Michael P. Makris, Jorge Fernando Maspero, Renaud Louis, Giorgio Walter Canonica, Eve Denton, Richard W. Costello, Chin Kook Rhee, Libardo Jiménez-Maldonado, Delbert R. Dorscheid, John Busby, John W. Upham, Michael E. Wechsler, George Christoff, Désirée Larenas‐Linnemann, John Townend, Peter G. Gibson, Todor A. Popov, ARNAUD AB BOURDIN, Petros Bakakos, María Eugenia Franchi, Francesca Puggioni, Peter G. Middleton, Ghislaine Scélo, Christine Jenkins, Alan Altraja, Ana María Stok, José Alberto Ferreira, Eileen Wang, Sverre Lehmann, David Price, Susanne Hansen, Charlotte Suppli Ulrik, Paul Pfeffer, Laila Salameh, Céline Bergeron, Κonstantinos Κostikas, Victoria Carter, Andréanne Côté, Patrick Mitchell, Borja G. Cosío, Flavia Hoyte, Mona Al‐Ahmad, M. Diane Lougheed, Carlos A. Torres‐Duque, Simon Couillard, Neda Stjepanovic, Yuji Tohda, Rohit Katial, Paulo Márcio Pitrez, Enrico Marco Heffler, Belinda Cochrane, Luis Pérez de Llano, Pin‐Kuei Fu, Diana Jimena Cano Rosales, Celeste Porsbjerg, Adeeb A. Bulkhi, Takashi Iwanaga, João Fonseca, Iván Solarte, Roy A. Pleasants, Cláudia Chaves Loureiro, Mark Hew, Aaron Beastall, Yah Ru Juang, Anqi Liu, Nikolaos G. Papadopoulos, Pujan H. Patel, David J. Jackson, Bassam Mahboub, Ming-Ju Tsai, Diahn‐Warng Perng, Bernt Bøgvald Aarli, Kenneth R. Chapman, Ledit Ardusso, Nevaashni Eleangovan, Anahí Yañez, Aggelos Ladias, Ana Giselle Tomaszuk, Bellanid Rodríguez-Cáceres
article en
11 citations

Abstract

Biologic initiation in patients with SA led to substantial reduction in TOCS exposure, particularly in the first year. Future analyses will explore the impact on OCS-related adverse health events.

The Journal of Allergy and Clinical Immunology In PracticeVol. 13(8)
AstraZeneca (United Kingdom) (GB), University of North Carolina at Chapel Hill (US), Queen's University Belfast (GB), National University of Tucumán (AR), Camden and Campbelltown Hospitals (AU), Centre National de la Recherche Scientifique (FR), Humanitas University (IT), Alfaisal University (SA), Université de Sherbrooke (CA), University of British Columbia (CA), Kaohsiung Medical University (TW), University of Alberta (CA), Inserm (FR), Universidad de La Sabana (CO), University of Liège (BE), The University of Queensland (AU), National University of Singapore (SG), Queen Mary University of London (GB), National Taiwan University (TW), Universidade do Porto (PT), King's College London (GB), University of Toronto (CA), University of Ioannina (GR), Université de Montpellier (FR), Umm al-Qura University (SA), Universidade de Santiago de Compostela (ES), National and Kapodistrian University of Athens (GR), Queen's University (CA), Trinity College Dublin (IE), Singapore General Hospital (SG), Barts Health NHS Trust (GB), Pontificia Universidad Javeriana (CO), University of Michigan (US), Vancouver Hospital and Health Sciences Centre (CA), John Hunter Hospital (AU), Santa Casa Hospital (BR), Haukeland University Hospital (NO), Rashid Hospital (AE), Woolcock Institute of Medical Research (AU), Frederiksberg Hospital (DK), Ghent University Hospital (BE), Beaumont Hospital (IE), King Fahd Medical City (SA), Bispebjerg Hospital (DK), Erasmus MC (NL), Hospitais da Universidade de Coimbra (PT), Tartu University Hospital (EE), Dubai Hospital (AE), Copenhagen University Hospital (DK), Vancouver General Hospital (CA), Taipei Veterans General Hospital (TW), Westmead Hospital (AU), University of Sharjah (AE), Medical University of Sofia (BG), National Jewish Health (US), UNSW Sydney (AU), Kuwait University (KW), National University of Rosario (AR), Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR), Hunter Medical Research Institute (AU), Taichung Veterans General Hospital (TW), Instituto del Corazón de Bucaramanga (CO), Kindai University Hospital (JP), Royal Brompton Hospital (GB), Hospital Universitario Austral (AR), Hospital Médica Sur (MX), Hospital Ramos Mejía (AR), University Hospital St. Ivan Rilski (BG), ENT and Allergy (US), The George Institute for Global Health (AU), Laiko General Hospital of Athens (GR), Observational & Pragmatic Research Institute (SG), Fundación Neumológica Colombiana (CO), Monash Health (AU), Medical University of Lodz (PL), Health Research Institute of the Balearic Islands (ES), Centro Científico Tecnológico - Tucumán (AR), Ministry of Health (KW), National Taiwan University Hospital (TW), Hospital Donación Francisco Santojanni (AR), Asociación por los Derechos Civiles (AR), Centre for Health Technology and Services Research (PT), Asociación Psicoanalítica de Buenos Aires (AR), AstraZeneca (Italy) (IT), University General Hospital Attikon (GR), Centro Hospitalar de Vila Nova de Gaia (PT), University Hospital of Ioannina (GR), AstraZeneca (Sweden) (SE), National University Hospital (SG), National University Health System (SG), AstraZeneca (United States) (US), Favaloro Foundation (AR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), IRCCS Humanitas Research Hospital (IT), Alfred Health (AU), Université Laval (CA), University of Tartu (EE), Monash University (AU), Kobe University (JP), Athens State University (US), University of Coimbra (PT), Catholic University of Korea (KR), University of Colorado Denver (US), Macquarie University (AU)
American Thoracic Society, Amgen, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Sanofi, Gilead Sciences, Teva Pharmaceutical Industries, United Therapeutics Corporation, Chiesi Farmaceutici, Danone, CSL Behring, European Respiratory Society, Regeneron Pharmaceuticals, Canadian Thoracic Society, Covis Pharma, Government of Ontario, Cerecor, British Columbia Lung Association, Allergy Therapeutics, Optimum Patient Care, Incyte, Celltrion, Horizon Therapeutics, Glenmark Pharmaceuticals, Insmed, Canadian Lung Association, Michael Smith Health Research BC, National Institute for Health and Care Research, Singapore General Hospital, Kuwait Foundation for the Advancement of Sciences, Queen's University, University of Toronto, Meiji Seika Pharma, Novo Nordisk, Shionogi, Teijin Pharma, Grifols, Genentech, Novartis Pharmaceuticals UK Limited, Sanofi Genzyme, Canadian Institutes of Health Research, Medical Research Council, Efficacy and Mechanism Evaluation Programme, Department of Medicine, University of Toronto, UCB Pharma, Daiichi Sankyo Europe
Partnerships for the goals
Openalex Percentile: Top 1%
Asthma and respiratory diseases
12.81
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