Single nucleotide polymorphisms and penicillin non-susceptibility among invasive Streptococcus pneumoniae from Vietnam and India: Insights from a comparative genomics study

The current study highlights the genetic basis of penicillin non-susceptibility among invasive S. pneumoniae serotypes 23F and 19F and focuses on regional variations in resistance between India and Vietnam. The pbpX was identified as a core gene among penicillin-resistant pneumococci in Vietnam. In India, the absence of pbpX highlights genomic diversity, distinct from the uniformity observed in Vietnamese genomes. The study further predicts that deleterious SNPs are associated with pathogenicity.