Investigation of the Impact of Deep Brain Stimulation of the Subthalamic Nucleus on Parkinson Disease Patients with Genetic Risk Factors/Causes
STN-DBS demonstrated benefits for patients with PD across all genetic backgrounds, but LRRK2 carriers may require increasing stimulation over time, while GBA carriers show reduced motor and quality-of-life improvements.
Authors
- Xiaosheng Zheng (ORCID: https://orcid.org/0000-0001-6486-5079)
- Zhidong Cen (ORCID: https://orcid.org/0000-0003-3155-5781)
- Wei Luo (ORCID: https://orcid.org/0000-0001-6951-7698)
- Fei Xie (ORCID: https://orcid.org/0000-0003-0505-0229)
- S. Z. Wu (ORCID: https://orcid.org/0000-0001-7330-8872)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- World Neurosurgery
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1016/j.wneu.2025.124021
- Citations
- 1
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43