Impact of mepolizumab on the AAV-PRO questionnaire in eosinophilic granulomatosis with polyangiitis: data from a European multicentre study
Mepolizumab was associated with a quick and remarkable improvement of health-related quality of life in patients with EGPA. These findings highlight its early and sustained benefits beyond disease control and support the integration of the AAV-PRO questionnaire into routine clinical practice.
Authors
- Georgina Espígol‐Frigolé (ORCID: https://orcid.org/0000-0002-8299-0209)
- Maria Letizia Urban
- Claire de Moreuil (ORCID: https://orcid.org/0000-0003-1142-0978)
- L Ricciardi (ORCID: https://orcid.org/0000-0003-3105-8347)
- Roberto Padoan (ORCID: https://orcid.org/0000-0002-2356-375X)
- Virginia Valeria Ferretti (ORCID: https://orcid.org/0000-0003-0130-915X)
- Anna Kernder (ORCID: https://orcid.org/0000-0002-7742-7526)
- Diego Bagnasco (ORCID: https://orcid.org/0000-0002-3661-5731)
- Carlomaurizio Montecucco (ORCID: https://orcid.org/0000-0001-8263-3925)
- Franco Franceschini (ORCID: https://orcid.org/0000-0003-3678-6124)
- Augusto Vaglio (ORCID: https://orcid.org/0000-0002-3814-9172)
- Alvise Berti (ORCID: https://orcid.org/0000-0002-7831-921X)
- Elena Treppo (ORCID: https://orcid.org/0000-0002-4731-9882)
- Alessandra Milanesi (ORCID: https://orcid.org/0000-0001-8353-5147)
- Joanna Robson (ORCID: https://orcid.org/0000-0002-7939-5978)
- Erika Manna
- Luca Quartuccio (ORCID: https://orcid.org/0000-0002-0134-6439)
- Federico Alberici (ORCID: https://orcid.org/0000-0002-1686-5709)
- Jan Walter Schroeder (ORCID: https://orcid.org/0000-0001-5237-3720)
- Giulia Anna Maria Luigia Costanzo (ORCID: https://orcid.org/0000-0003-2269-0439)
- Laura Losappio (ORCID: https://orcid.org/0000-0001-6096-650X)
- María C. Cid (ORCID: https://orcid.org/0000-0002-4730-0938)
- Francesca Regola (ORCID: https://orcid.org/0000-0001-6560-1112)
- Edoardo Conticini (ORCID: https://orcid.org/0000-0002-3974-6606)
- Giacomo Emmi (ORCID: https://orcid.org/0000-0001-9575-8321)
- Francesca Torracca
- Simone Matteo Negrini (ORCID: https://orcid.org/0000-0003-1267-4320)
- Catherine Klersy (ORCID: https://orcid.org/0000-0003-0314-8548)
- Stefano R. Del Giacco (ORCID: https://orcid.org/0000-0002-4517-1749)
- Paola Toniati
- Sara M. Monti (ORCID: https://orcid.org/0000-0002-1800-6772)
- Alberto Lo Gullo (ORCID: https://orcid.org/0000-0003-4383-0314)
- Luca Iorio (ORCID: https://orcid.org/0009-0000-2388-7001)
- Paolo Delvino (ORCID: https://orcid.org/0000-0002-6383-8236)
- Marta Camoni
- Marco Caminati (ORCID: https://orcid.org/0009-0009-1134-059X)
- Benjamin Terrier (ORCID: https://orcid.org/0000-0001-6612-7336)
- Matteo Maule
Institutions
- University of Siena (IT)
- University of Messina (IT)
- University of Verona (IT)
- University of Udine (IT)
- University of Padua (IT)
- University of Trieste (IT)
- Nara University (JP)
- University of Cagliari (IT)
- University of the West of England (GB)
- University of Trento (IT)
- Université Paris Cité (FR)
- University of Pavia (IT)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Brescia University (US)
- Ospedale Santa Chiara (IT)
- Düsseldorf University Hospital (DE)
- Sorbonne Paris Cité (FR)
- Rheumazentrum Ruhrgebiet (DE)
- Hôpital Cochin (FR)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Ospedale di Cattinara (IT)
- Surgical Specialties (Canada) (CA)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Meyer Children's Hospital (IL)
- Ospedale Garibaldi (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Meyer Children's Hospital (IT)
- Hospital Clínic de Barcelona (ES)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Centre Hospitalier Régional Universitaire de Brest (FR)
- IRCCS Istituto Auxologico Italiano (IT)
- Ospedale Policlinico San Martino (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University Hospitals Bristol and Weston NHS Foundation Trust (GB)
- Heinrich Heine University Düsseldorf (DE)
- University of Florence (IT)
- University of Milano-Bicocca (IT)
- Universitat de Barcelona (ES)
- University of Brescia (IT)
- University of Genoa (IT)
- Advanced Research Projects Agency - Energy (US)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1093/rheumatology/keaf232
- Citations
- 3
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Eli Lilly and Company
- AstraZeneca