Patient and Caregiver Perspectives on the Design and Execution of ACT-GLOBAL, a Stroke Adaptive Platform Trial: A Focus Group Study
Patient-partners were supportive of an adaptive platform trial design. However, they expressed important priorities in their execution while safeguarding patient autonomy and safety. Oversight, multiple modes of delivering patient information, and having feedback evaluation and transparency with ongoing participation were identified as valued components. Deferral of consent was recognized as a pragmatic way to enroll patients. Similar considerations may apply to adaptive platform trials in other neurological/medical emergencies.
Authors
- R. Wilson
- Aravind Ganesh (ORCID: https://orcid.org/0000-0001-5520-2070)
- Nora Cristall (ORCID: https://orcid.org/0000-0001-7423-2785)
- Brian Dewar (ORCID: https://orcid.org/0000-0002-9222-5420)
- Michel Christopher Frank Shamy (ORCID: https://orcid.org/0000-0002-0085-6816)
- Nishita Singh (ORCID: https://orcid.org/0000-0003-3647-0904)
- Ivy Sebastian (ORCID: https://orcid.org/0000-0002-9196-3130)
- Bijoy K. Menon (ORCID: https://orcid.org/0000-0002-3466-496X)
- Xiaoying Chen (ORCID: https://orcid.org/0000-0002-8367-542X)
- Michael D. Hill (ORCID: https://orcid.org/0000-0002-6269-1543)
- Craig S. Anderson
- Carol Kenney
Institutions
- Manitoba Health (CA)
- University of Ottawa (CA)
- University of Calgary (CA)
- Christian Medical College, Vellore (IN)
- Ottawa Hospital (CA)
- UNSW Sydney (AU)
- O'Brien Institute (AU)
- Christian Medical College (IN)
- The George Institute for Global Health (AU)
- Ottawa Hospital Research Institute (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- Cerebrovascular Diseases
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1159/000546132
- Primary Topic
- Meta-analysis and systematic reviews
- Type
- article
- Field-Weighted Citation Impact
- 0.00