Existence of Coexpressive Role of Kisspeptin and Insulin-2 in the Regulation of Luteinizing Hormone in Chronic Stress-Induced Polycystic Ovarian Syndrome-Like Phenotype in Rattus norvegicus
The obtained relative fold changes in the gene expression level of both KiSS1 and INS2 reveal the association of stress with the pathology of PCOS via neuroendocrine regulation. The study has demonstrated the existence of a putative temporal coupling activity of KiSS1-INS2 expression-driven elevated LH in preclinical Rattus norvegicus models.
Authors
- Raghu Nataraj (ORCID: https://orcid.org/0000-0002-2108-0850)
- Nitin Kalsi Rajashekara
- Bindu Jayashankaraswamy
Institutions
- JSS Academy of Higher Education and Research (IN)
- JSS Science and Technology University (IN)
Publication Details
- Journal
- Neuroendocrinology
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1159/000546126
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- JSS Academy of Higher Education and Research