TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis
The OM of a subset of patients with sporadic MND can trigger seeding activity for TDP-43, as previously observed in genetic MND. Thus, TDP-43_SAA analysis of OM can improve the clinical characterization of ALS across different phenotypes and enhance our understanding of these diseases. Finally, plasma TDP-43 could serve as a potential biomarker for monitoring disease progression. However, further research is needed to confirm and expand these findings.
Authors
- Giuseppe Legname (ORCID: https://orcid.org/0000-0003-0716-4393)
- Valerio Margiotta
- Annalisa Lombardo
- Riccardo Pascuzzo (ORCID: https://orcid.org/0000-0001-6555-1784)
- Arianna Ciullini (ORCID: https://orcid.org/0009-0009-6013-6093)
- Eleonora Dalla Bella (ORCID: https://orcid.org/0000-0001-6267-9651)
- Luigi Celauro (ORCID: https://orcid.org/0000-0002-5731-3257)
- Emilio Ciusani (ORCID: https://orcid.org/0000-0002-7285-123X)
- Sara Maria Portaleone
- Marcella Catania (ORCID: https://orcid.org/0000-0003-0370-1905)
- Giuseppe Lauria (ORCID: https://orcid.org/0000-0001-9773-020X)
- Pietro Tiraboschi (ORCID: https://orcid.org/0000-0002-2171-1720)
- Maria Vizziello (ORCID: https://orcid.org/0000-0002-7005-689X)
- Fabio Moda (ORCID: https://orcid.org/0000-0002-2820-9880)
- Veronica Faltracco
- Ambra Rizzo (ORCID: https://orcid.org/0000-0003-2134-5414)
- Francesco Bellandi
- Gianluigi Zanusso (ORCID: https://orcid.org/0000-0001-5199-6264)
- Nilo Riva (ORCID: https://orcid.org/0000-0002-0513-9517)
- Grazia Devigili (ORCID: https://orcid.org/0000-0001-9688-4231)
- Ilaria Linda Dellarole (ORCID: https://orcid.org/0009-0007-8422-4552)
- Monica Consonni (ORCID: https://orcid.org/0000-0002-0479-2290)
- Claudia Battipaglia
- Sara Adriana Della Seta
Institutions
- University of Verona (IT)
- AOL (United States) (US)
- Scuola Internazionale Superiore di Studi Avanzati (IT)
- University of Milan (IT)
- Ospedale San Paolo (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s13024-025-00833-0
- Citations
- 8
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- Ministero della Salute