Comprehensive comparative analysis of infrapatellar fat pad morphologies in a longitudinal knee osteoarthritis exploratory study: new insights into its role as an independent prognostic marker

This longitudinal exploratory study, leveraging a fully automated technology, highlights that i) IPFP volume (global and both signals) is superior to area metrics in predicting long-term structural changes in OA, and ii) smaller IPFP volume and area are linked with reduced need for KR. These findings provide new insights into the usefulness of IPFP morphology as a predictive biomarker of knee OA outcomes, offering a new approach to stratifying knee OA patients.