Dynamics of tertiary lymphoid structures and immune cross talk in early versus advanced colorectal cancer: potential implications for immunotherapy
Our research shed light on the multilayered immune dysfunction in advanced CRC and elucidates the alterations in the TLS during the progression of CRC, providing insights for functional studies and the exploration of potential target in advanced CRC.
Authors
- Zhenyu Xian (ORCID: https://orcid.org/0000-0001-6132-6811)
- Han Gao (ORCID: https://orcid.org/0000-0002-7900-9483)
- Zixu Chen (ORCID: https://orcid.org/0000-0002-7305-9711)
- Qian Zhou (ORCID: https://orcid.org/0000-0003-3954-5449)
- Keyu Cai
- Qi Zou (ORCID: https://orcid.org/0000-0003-1337-5154)
- Donglin Ren (ORCID: https://orcid.org/0000-0002-6105-8009)
- Zhen Fang (ORCID: https://orcid.org/0000-0002-9336-0421)
- Bang Hu
- Shuang Zhang (ORCID: https://orcid.org/0000-0003-4927-7230)
Institutions
- Qingdao University (CN)
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1007/s00262-025-04027-x
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Traditional Chinese Medicine Bureau of Guangdong Province