Metabolic effects of high-dose glucocorticoid following out-of-hospital cardiac arrest
In this exploratory study, early administration of 250 mg of methylprednisolone after resuscitation appeared to drive sustained metabolic effects over 48 h. Specifically, methylprednisolone led to reductions in ω-6 fatty acids and increases in several amino acids, with a notable rise in tryptophan.
Authors
- Rasmus Paulin Beske (ORCID: https://orcid.org/0000-0002-5880-3733)
- Christian Hassager (ORCID: https://orcid.org/0000-0002-1199-0981)
- Jesper Kjærgaard (ORCID: https://orcid.org/0000-0001-5244-0399)
- Pär I. Johansson (ORCID: https://orcid.org/0000-0001-9778-5964)
- M Meyer (ORCID: https://orcid.org/0000-0002-6312-2457)
- Laust Emil Roelsgaard Obling (ORCID: https://orcid.org/0000-0003-2927-3670)
- Jacob Eifer Møller (ORCID: https://orcid.org/0000-0003-2873-5845)
Institutions
- University of Copenhagen (DK)
- Odense University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s40635-025-00754-8
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Københavns Universitet
- Gentofte Hospital
- Rigshospitalet