The Virtual Parkinsonian patient
This study investigates the influence of the pharmacological nigrostriatal dopaminergic stimulation on the entire brain by analyzing EEG and deep electrodes, placed near the subthalamic nuclei, from 10 Parkinsonian patients before (OFF) and after (ON) L-Dopa administration. We characterize large-scale brain dynamics as the spatio-temporal spreading of aperiodic bursts. We then simulate the effects of L-Dopa utilizing a novel neural-mass model that includes the local dopamine concentration. Whole-brain dynamics are simulated for different dopaminergic tones, generating predictions for the expected dynamics, to be compared with empirical EEG and deep electrode data. To this end, we invert the model and infer the most likely dopaminergic tone from empirical data, correctly identifying a higher Dopaminergic tone in the ON-state, and a lower dopaminergic tone in the OFF-state, for each patient. In conclusion, we successfully infer the dopaminergic tone by integrating anatomical and functional knowledge into physiological predictions, using solid ground truth to validate our findings.
Authors
- Pierpaolo Sorrentino (ORCID: https://orcid.org/0000-0002-9556-9800)
- Abolfazl Ziaeemehr (ORCID: https://orcid.org/0000-0002-4696-9947)
- Damien Depannemaecker (ORCID: https://orcid.org/0000-0003-1936-4560)
- Paul Triebkorn (ORCID: https://orcid.org/0000-0002-0371-8400)
- Marianna Angiolelli (ORCID: https://orcid.org/0000-0001-9717-0572)
- Jean Marie Régis (ORCID: https://orcid.org/0000-0002-4842-3753)
- Viktor Jirsa (ORCID: https://orcid.org/0000-0002-8251-8860)
- Marmaduke Woodman (ORCID: https://orcid.org/0000-0002-8410-4581)
- Meysam Hashemi (ORCID: https://orcid.org/0000-0001-5289-9837)
- Hasnae Agouram
- Letizia Chiodo
- Romain Carron (ORCID: https://orcid.org/0000-0002-4723-7406)
- Alexandre Eusébio (ORCID: https://orcid.org/0000-0003-4923-0248)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Università Campus Bio-Medico (IT)
- Aix-Marseille Université (FR)
- Institut de Neurosciences des Systèmes (FR)
- Institut de Neurosciences de la Timone (FR)
- Hôpital de la Timone (FR)
Publication Details
- Journal
- npj Systems Biology and Applications
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1038/s41540-025-00516-y
- Citations
- 9
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.50
Funders
- Istituto Nazionale di Alta Matematica "Francesco Severi"
- European Commission
- Gruppo Nazionale per la Fisica Matematica