Paradoxical Maturity-Onset Diabetes of the Young Arising From Loss-of-Function Mutations in ATP-Sensitive Potassium Channels
Gain-of-function (GOF) ATP-sensitive K+ (KATP) mutations cause neonatal diabetes mellitus. KATP mutations are also associated with maturity-onset diabetes of the young (MODY), but the molecular cause is not clear. What are the molecular consequences of MODY-associated KATP mutations? KATP mutations from a large group of patients with MODY were all associated with loss-of-function (LOF) of different molecular etiologies. There are two distinct forms of KATP-associated MODY resulting from GOF and LOF, respectively, with very different clinical and therapeutic implications.
Authors
- Ranjit Mohan Anjana (ORCID: https://orcid.org/0000-0002-4843-1374)
- B Kavitha
- Ranjit Unnikrishnan (ORCID: https://orcid.org/0000-0002-8587-8861)
- Jian Gao (ORCID: https://orcid.org/0000-0003-0253-3217)
- Viswanathan Mohan (ORCID: https://orcid.org/0000-0001-5038-6210)
- Sundaramoorthy Gopi
- Colin G. Nichols (ORCID: https://orcid.org/0000-0002-4929-2134)
- Yunpeng Li (ORCID: https://orcid.org/0000-0003-4122-6957)
- N York (ORCID: https://orcid.org/0000-0002-0179-0900)
- Venkatesan Radha (ORCID: https://orcid.org/0000-0002-4281-0250)
- Rosa Scala (ORCID: https://orcid.org/0009-0002-1370-2012)
Institutions
- Washington University in St. Louis (US)
- Regional Medical Research Centre (IN)
- Madras Diabetes Research Foundation (IN)
- Dr. Mohan's Diabetes Specialities Centre (IN)
Publication Details
- Journal
- Diabetes
- Published
- 2025-04-24
- DOI
- https://doi.org/10.2337/db25-0110
- Citations
- 6
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 7.77