Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia
Activation of myocardial NHE1 promotes MLKL autophagic degradation, mitigating cardiomyocyte necroptosis and acute hyperglycemia-exacerbated MI, highlighting NHE1 as a hyperglycemia-dependent cardioprotective target. Moderate NHE1 activation may represent a novel therapeutic strategy for MI with acute hyperglycemia.
Authors
- Fanghua Su
- Ruhua Deng
- Lei Hou (ORCID: https://orcid.org/0000-0001-6578-1707)
- John Hwa (ORCID: https://orcid.org/0000-0001-7366-2628)
- Kai Jiang (ORCID: https://orcid.org/0000-0002-1917-0208)
- Yang Chen (ORCID: https://orcid.org/0000-0003-0308-6930)
- Dandan Wang (ORCID: https://orcid.org/0000-0001-7234-9517)
- Xun Yuan (ORCID: https://orcid.org/0009-0003-7285-3010)
- Lan Shen (ORCID: https://orcid.org/0000-0002-8332-2480)
- Yue Xu (ORCID: https://orcid.org/0000-0001-5953-4830)
- Anqi Qin
- Yaozu Xiang
- Dongmei Xing
Institutions
- Shanghai Chest Hospital (CN)
- Yale University (US)
- Institute of Biophysics (CN)
- Shanghai East Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s12933-025-02743-3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China