Hongjingtian alleviates arsenic-induced hepatocyte injury by inhibiting oxidative stress and endoplasmic reticulum stress
This study explored Hongjingtian's (HJT) protective effects against arsenic-induced hepatotoxicity. NaAsO<sub>2</sub> (8 μM, 24 h)-damaged hepatocytes treated with HJT (50/100 mg/L) showed restored cell viability via CCK-8/LDH assays. HJT reduced arsenic-induced ROS, improved mitochondrial membrane potential, elevated SOD/CAT activity, lowered MDA, and suppressed apoptosis by downregulating Caspase-3/Bax while upregulating Bcl-2. Additionally, HJT alleviated endoplasmic reticulum stress (ERS). Mechanistically, HJT attenuated arsenic-induced hepatocyte apoptosis by mitigating oxidative stress and ERS via ROS reduction.
Authors
- Hailong Lv (ORCID: https://orcid.org/0000-0002-2019-6376)
- Jiaqi Chen (ORCID: https://orcid.org/0000-0002-1643-5450)
- Yufeng Jiang (ORCID: https://orcid.org/0000-0003-4553-4834)
- Haiwen Li (ORCID: https://orcid.org/0000-0001-7223-1754)
- Cao Jiangtao
Institutions
- Chengdu Medical College (CN)
- Third People's Hospital of Chengdu (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1080/10286020.2025.2481290
- Citations
- 1
- Primary Topic
- Arsenic contamination and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- National Natural Science Foundation of China