Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated <scp>REM</scp> Sleep Behavior Disorder and Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface-based fluorescence intensity distribution analysis (sFIDA) to measure α-synuclein aggregates in urine. Patients with PD and isolated rapid eye movement sleep behavior disorder, a precursor to PD, had elevated concentrations compared with healthy controls. Sensitivity and specificity were 83% and 65% for PD versus controls and 89% and 62% for isolated rapid eye movement sleep behavior disorder versus controls. The findings highlight sFIDA's potential for diagnosing synucleinopathies. ANN NEUROL 2025;98:147-151.

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Publication Details

Journal
Annals of Neurology
Published
2025-04-26
DOI
https://doi.org/10.1002/ana.27250
Citations
6
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
8.34

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article

Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease

Aline Seger, Gereon R. Fink, Charlotte Schedlich‐Teufer, Hannah Jergas et al.
6 citations
Annals of Neurology
Parkinson's Disease Mechanisms and Treatments
8.34
article

Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease

Aline Seger, Gereon R. Fink, Charlotte Schedlich‐Teufer, Hannah Jergas, Gültekin Tamgüney, Michael Sommerauer, Michael T. Barbe, Pelin Özdüzenciler, Dieter Willbold, Laura Müller
article en
6 citations

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface-based fluorescence intensity distribution analysis (sFIDA) to measure α-synuclein aggregates in urine. Patients with PD and isolated rapid eye movement sleep behavior disorder, a precursor to PD, had elevated concentrations compared with healthy controls. Sensitivity and specificity were 83% and 65% for PD versus controls and 89% and 62% for isolated rapid eye movement sleep behavior disorder versus controls. The findings highlight sFIDA's potential for diagnosing synucleinopathies. ANN NEUROL 2025;98:147-151.

Annals of NeurologyVol. 98(1)
Forschungszentrum Jülich (DE), University of Cologne (DE), University Hospital Bonn (DE), University Hospital Cologne (DE), Heinrich Heine University Düsseldorf (DE)
Deutsche Forschungsgemeinschaft, Else Kröner-Fresenius-Stiftung, EIT Health
Good health and well-being
Openalex Percentile: Top 2%
Parkinson's Disease Mechanisms and Treatments
8.34
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Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated <scp>REM</scp> Sleep Behavior Disorder and Parkinson's Disease — Aline Seger, Gereon R. Fink, et al. · Annals of Neurology (2025) | TGRS Research Map | TGRS