Phosphatemia is an Independent Prognostic Factor in Amyotrophic Lateral Sclerosis
Creatininemia was confirmed as a prognostic marker in amyotrophic lateral sclerosis (ALS). Additionally, both phosphatemia levels at diagnosis and its rate of change over time were identified as a potential prognostic marker for ALS. As with other blood biomarkers, phosphate levels are cost-effective and minimally invasive to measure, supporting their potential use in clinical trials. ANN NEUROL 2025;98:286-293.
Authors
- F Vergnano
- Cecilia Simonini (ORCID: https://orcid.org/0000-0001-5456-2365)
- Fabiola De Marchi (ORCID: https://orcid.org/0000-0003-4366-0167)
- Antonio Canosa (ORCID: https://orcid.org/0000-0001-5876-4079)
- Ilaria Martinelli (ORCID: https://orcid.org/0000-0003-2566-3671)
- Enrico Matteoni (ORCID: https://orcid.org/0009-0008-2963-8821)
- Andrea Calvo (ORCID: https://orcid.org/0000-0002-5122-7243)
- Umberto Manera (ORCID: https://orcid.org/0000-0002-9995-8133)
- Jessica Mandrioli (ORCID: https://orcid.org/0000-0002-9244-9782)
- Emanuele Koumantakis (ORCID: https://orcid.org/0000-0001-6994-8375)
- Sara Cabras (ORCID: https://orcid.org/0000-0002-4988-2855)
- Maurizio Grassano (ORCID: https://orcid.org/0000-0001-6714-6897)
- Rosario Vasta (ORCID: https://orcid.org/0000-0002-0393-4736)
- Filippo De Mattei
- Francesca Palumbo (ORCID: https://orcid.org/0000-0002-7070-2409)
- Francesca Di Pede (ORCID: https://orcid.org/0000-0001-8959-0614)
- Adriano Chiò (ORCID: https://orcid.org/0000-0001-9579-5341)
- Cristina Moglia
- Letizia Mazzini
Institutions
- Università di Camerino (IT)
- University of Modena and Reggio Emilia (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- National Research Council (IT)
- Institute of Cognitive Sciences and Technologies (IT)
- University of Turin (IT)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1002/ana.27252
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- European Commission
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca