Biochemical implementation of acceleration sensing and PIDA control
This work introduces a realization of a proportional-integral-derivative-acceleration control scheme as a chemical reaction network governed by mass action kinetics. A central feature of this architecture is a speed and acceleration biosensing mechanism integrated into a feedback configuration. Our control scheme provides enhanced dynamic performance and robust steady-state tracking. In addition to our theoretical analysis, this is practically highlighted in-silico in both the deterministic and stochastic settings.
Authors
- Emmanouil Alexis (ORCID: https://orcid.org/0000-0002-1537-7711)
- Sebastián Espinel‐Ríos (ORCID: https://orcid.org/0000-0002-1582-6169)
- Ioannis G. Kevrekidis (ORCID: https://orcid.org/0000-0003-2220-3522)
- José L. Avalos (ORCID: https://orcid.org/0000-0002-7209-4208)
Institutions
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Johns Hopkins University (US)
- Princeton University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- npj Systems Biology and Applications
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1038/s41540-025-00514-0
- Primary Topic
- Gene Regulatory Network Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- U.S. Department of Energy