In silico-based analysis and in vitro experiments identify SIGMAR1 as a potential marker of putative lung cancer stem cells
We propose that SIGMAR1 serves as a potential functional marker of CSCs and plays a crucial role in regulating self-renewal capacity. Targeting SIGMAR1 may provide a novel therapeutic strategy for preventing metastasis and recurrence-major clinical challenges in lung cancer treatment. Future studies should investigate the underlying mechanisms by which SIGMAR1 modulates CSC properties.
Authors
- Ikuhiro Tanida
- Tetsuhiro Horie (ORCID: https://orcid.org/0000-0002-2095-9425)
- Yasuhito Ishigaki (ORCID: https://orcid.org/0000-0003-1012-8430)
- Ayane Kuwano
- Takuya Sakamoto (ORCID: https://orcid.org/0000-0003-2519-4510)
- Satoshi Osawa (ORCID: https://orcid.org/0000-0003-3414-1808)
- Kazuo Yasumoto (ORCID: https://orcid.org/0000-0002-7890-4929)
- Yuka Nakamura (ORCID: https://orcid.org/0000-0002-4803-2111)
- Kayoko Yamaguchi
Institutions
- Kanazawa Institute of Technology (JP)
- Kanazawa Medical University (JP)
- Kanazawa Medical University Hospital (JP)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1007/s12672-025-02394-6
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Tokyo
- Japan Society for the Promotion of Science