HBV activates hepatic stellate cells through RUNX2/ITGBL1 axis
RUNX2 promotes liver fibrosis in HBV-infected patients by upregulating ITGBL1 expression. Our findings suggest that targeting RUNX2 could be a potential therapeutic approach to mitigate liver fibrosis in chronic hepatitis B.
Authors
- Wei Tan (ORCID: https://orcid.org/0000-0002-6515-2887)
- Demin Yu (ORCID: https://orcid.org/0000-0001-9441-8616)
- Fengchun Shi (ORCID: https://orcid.org/0000-0003-2459-4280)
- Yong-Xiang Wang (ORCID: https://orcid.org/0000-0003-1405-7131)
- Wei Huang
- Fei Ye (ORCID: https://orcid.org/0000-0001-7734-8257)
- Xinxin Zhang (ORCID: https://orcid.org/0000-0002-0598-6425)
- Mingjie Wang (ORCID: https://orcid.org/0000-0002-5680-2390)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Central South University (CN)
- Shanghai Jiao Tong University (CN)
- Nantong University (CN)
- Ruijin Hospital (CN)
- Affiliated Hospital of Nantong University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s12985-025-02749-z
- Citations
- 3
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- China Postdoctoral Science Foundation