Measurement of Insulin Resistance in Cats With Chronic Kidney Disease

Our findings indicate that, unlike in humans, insulin levels and HOMA-IR are lower in cats with CKD, suggesting a potential mechanism of β-cell dysfunction and reduced insulin secretion contributing to hyperglycaemia. Future research focused on oxidative stress in conjunction with pro-inflammatory cytokines, inflammatory mediators and serum fPLI concentrations may be crucial for understanding the pathogenesis of hypoinsulinaemia in cats with CKD.