Multifacet role of JAKs in chronic myeloid leukemia

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is an essential cell signaling system that plays a significant role in the production of blood cells and regulates the growth, differentiation, and function of immune cells. Numerous hematological disorders can result from mutations that target this system, which can cause an excess of these cell types. This commentary perspectives JAKs in leukemia and also in chronic myeloid leukemia. This commentary also covers the relevant mutations and drug-targets for JAKs as well as the current therapeutic strategies for preventing constitutive, cytokine-independent pathway activation.