Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria

The misuse of antibiotics results in the emergence of a large number of drug-resistant bacteria, which leads to huge financial and social burdens. Exploring artificial nanozymes is regarded as a promising candidates for the substitution of antibiotics, but still remain a huge challenge. Herein, a new strategy is reported for constructing polymetallic indium coordination node Metal-organic frameworks (MOFs) (polyIn-BTB) for enhancing the production of reactive oxygen species (ROS), which significantly promote antibacterial activity. Theoretical research reveals that, compared to monometallic indium coordination node MOFs (monoIn-BTB), polyIn-BTB exhibits a stronger electron-donating ability, which can facilitate the efficient production of ROS. Thus, polyIn-BTB shows outstanding antibacterial properties of 87.0% and 92.0% for Methicillin-Resistant Staphylococcus aureus (MRS. aureus) and Escherichia coli (E. coli) respectively, which is significantly higher than that of monoIn-BTB (42% for MRS. Aureus and 50% for E. coli). The in vivo experiments demonstrate that polyIn-BTB accelerates wound healing by killing bacteria and inhibiting the inflammatory response they cause, with a wound healing rate of 98.0% in 8 days. Overall, this work reports a new strategy for constructing polyIn-BTB for enhancing the antibacterial performance, which opens the door to fundamental research on designing the nanozyme with high performance.