Causal effect of gut microbiota on the risk of cancer and potential mediation by inflammatory proteins
Our study provides evidence for a causal association between gut microbiota, inflammatory proteins, and eighteen different cancer types. Notably, the T-cell surface glycoprotein CD5 and CCL4 were identified as mediators linking the genus Collinsella with lung cancer and the genus Ruminococcaceae UCG005 with mesothelioma, respectively.
Authors
- Wanli Liu (ORCID: https://orcid.org/0000-0002-7467-760X)
- Yao Wang (ORCID: https://orcid.org/0000-0003-4115-9571)
- Liwen Liu (ORCID: https://orcid.org/0000-0001-9838-5727)
- Yanli He
- Huanhuan Luo (ORCID: https://orcid.org/0000-0003-1935-8240)
- Cantu Fang (ORCID: https://orcid.org/0000-0003-0984-7067)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s12957-025-03822-1
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61