Causal roles of lipids and mediating proteins in diabetic retinopathy: insights from metabolomic and proteomic Mendelian randomization
This study identifies specific plasma proteins that mediate the effects of lipids and metabolites on DR, establishing a direct molecular link between these biomarkers and disease progression. These findings enhance our understanding of the pathophysiological mechanisms underlying DR and highlight potential targets for therapeutic intervention.
Authors
- Danyan Liu (ORCID: https://orcid.org/0000-0002-7759-6186)
- Jing Su (ORCID: https://orcid.org/0000-0003-4272-4974)
- Jiawei Wang (ORCID: https://orcid.org/0009-0005-9092-768X)
- Jing Ma (ORCID: https://orcid.org/0000-0001-8248-9783)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s13098-025-01701-z
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hebei Medical University