Granulosa cell RNA-Seq insights into senescence and sphingolipid metabolism disorder in PCOS: aspirin as a potential therapeutic drug
This study highlighted the important value of genes associated with senescence and sphingolipids dysregulation in PCOS. Aspirin targeting senescence could be a promising therapeutic drug for addressing anovulation associated with PCOS.
Authors
- Yang Shen (ORCID: https://orcid.org/0000-0002-3313-5062)
- Weiwei Shi (ORCID: https://orcid.org/0009-0002-8282-7193)
- Di Wu
- Cong He (ORCID: https://orcid.org/0000-0002-1185-5456)
- Hao Lin (ORCID: https://orcid.org/0000-0001-7981-7707)
Institutions
- Jiangsu Second Normal University (CN)
- Zhongda Hospital Southeast University (CN)
- Southeast University (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-04-26
- DOI
- https://doi.org/10.1186/s12958-025-01396-x
- Citations
- 6
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Southeast University