Malignant Conjunctival Melanoma: A Case Report Study

Context: Melanocytic lesions are the most common tumors of the conjunctiva and are known for their recurrent potential. The aim of our study was to present the clinical and therapeutic evolution of a case of conjunctival melanoma managed in our healthcare facility. Case Presentation: We report the case of a 28-year-old male businessman who presented with a large, lobulated, and heavily pigmented lesion located in the superior and inferior fornices, initially suspected to be a recurrent nevus. Clinical and radiological assessments led to the diagnosis of conjunctival melanoma. Despite orbital exenteration and adjuvant chemotherapy, a recurrence of the tumor was observed five months after treatment. Discussion: This case highlights the therapeutic challenges and the lack of understanding regarding the molecular mechanisms underlying the recurrent nature of conjunctival melanoma, despite surgical and chemotherapeutic interventions. A deeper exploration of poor prognostic factors may enhance our understanding of these recurrence and guide us toward new therapeutic strategies. Conclusion: Conjunctival melanoma remains a malignant tumor with complex therapeutic management, and its recurrent mechanisms are yet to be fully understood.