CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB
Our findings indicate that circPAFAH1B2 acts as a molecular decoy blocking ClpB mitochondrial translocation, driving mitochondria-dependent cartilage degradation, which may provide novel therapeutic targets for OA.
Authors
- Yufan Bu
- Jiangdong Ren
- Yuhong Wei (ORCID: https://orcid.org/0000-0002-5333-5547)
- Chang Zhao
- T. Zhang
- Haosheng Li (ORCID: https://orcid.org/0000-0001-5446-9929)
- Lili Mu (ORCID: https://orcid.org/0000-0002-5439-5103)
- Lingxiang Chen (ORCID: https://orcid.org/0000-0002-4324-0915)
- Han Wu (ORCID: https://orcid.org/0000-0002-9829-3600)
- Guangyao Li (ORCID: https://orcid.org/0000-0003-0098-3433)
- Dong Wang (ORCID: https://orcid.org/0000-0002-4235-8719)
- Shu Hu (ORCID: https://orcid.org/0000-0002-5183-5791)
- Guoqing Liao (ORCID: https://orcid.org/0000-0002-5967-0282)
- Kaiyuan Zhu (ORCID: https://orcid.org/0009-0002-5167-1130)
- Guangxin Huang
- Y. K. Que (ORCID: https://orcid.org/0009-0001-0468-6631)
- Yifang Qian
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Shenzhen Sixth People's Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-04-24
- DOI
- https://doi.org/10.1016/j.jare.2025.04.024
- Citations
- 3
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42