Topical ruxolitinib in combination with oral minoxidil results in hair regrowth in a patient with central centrifugal cicatricial alopecia and concomitant traction alopecia

Central centrifugal cicatricial alopecia (CCCA) is a lymphocyte-predominant scarring disorder of the scalp characterized by hair loss at the vertex or crown that expands centrifugally. This disorder disproportionately affects adult women of African descent, with an estimated prevalence of 2.5% to 5.7%.1 CCCA can significantly impact patients’ quality of life, especially when traditional treatment proves ineffective. First-line therapy for CCCA includes topical or intralesional corticosteroids and oral tetracyclines to target follicular inflammation.