Lung lesion detectability on images obtained from decimated and CNN-based denoised [18F]-FDG PET/CT scan: an observer-based study for lung-cancer screening
Lung lesion detectability was preserved down to 30% of injected activity without denoising and to 10% with denoising. These results support the feasibility of reduced-activity [<sup>18</sup>F]-FDG PET/CT as a potential tool for lung lesion detection. Further studies are warranted to compare this approach with low-dose CT in screening settings.
Authors
- Mario Jreige (ORCID: https://orcid.org/0000-0003-3918-150X)
- Joshua Schaefferkoetter (ORCID: https://orcid.org/0000-0001-8249-4865)
- John Olivier Prior (ORCID: https://orcid.org/0000-0003-1429-1374)
- Siria Medici (ORCID: https://orcid.org/0000-0002-2909-6689)
- Adrien Depeursinge (ORCID: https://orcid.org/0000-0002-2362-0304)
- Marie Nicod Lalonde (ORCID: https://orcid.org/0000-0002-4886-0611)
- Daphné Faist (ORCID: https://orcid.org/0000-0002-0994-4329)
- Silvano Gnesin (ORCID: https://orcid.org/0000-0002-6547-3824)
- Niklaus Schaefer (ORCID: https://orcid.org/0000-0002-9732-7696)
- Maurizio Conti (ORCID: https://orcid.org/0000-0001-8215-4836)
- Asif Khan (ORCID: https://orcid.org/0000-0001-9158-0116)
Institutions
- HES-SO University of Applied Sciences and Arts Western Switzerland (CH)
- Medical Solutions (GB)
- HES-SO Valais-Wallis (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-04-25
- DOI
- https://doi.org/10.1007/s00259-025-07259-2
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois
- H2020 European Research Council