LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis <i>via</i> miR-625-5p/SCL7A11 axis
Inhibition of the lncRNA FTX/miR-625-5p/SLC7A11 axis can induce ferroptosis and disturb intracellular redox balance, further sensitizing CRC cells to ionizing radiation, suggesting its potential as a therapeutic target for improving CRC response to radiation therapy.
Authors
- Huangfei Yu
- Jinlan Yang
- Tianyin Qu
- Kaichun Wu (ORCID: https://orcid.org/0000-0002-0699-9666)
- Qing Dai (ORCID: https://orcid.org/0000-0002-1750-0867)
- Jingjing Ma (ORCID: https://orcid.org/0000-0002-2548-5871)
- Jie Wu (ORCID: https://orcid.org/0000-0003-4245-875X)
- Lin Fang (ORCID: https://orcid.org/0000-0003-2418-3617)
- Qianqian Zhu (ORCID: https://orcid.org/0000-0002-6897-136X)
- Jing Leng (ORCID: https://orcid.org/0000-0001-6115-2153)
Institutions
- First People’s Hospital of Zunyi (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3748/wjg.v31.i16.104305
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81