Fortified Withaferin A accelerates the transition from fibrovascular to bone remodeling phase during endochondral bone formation to promote ossification
These results demonstrate that FWA (10% w/w) could significantly enhance bone mineralization and healing, facilitating an earlier transition from fibrovascular tissue to bone remodeling. The enhanced results, such as increased healing, better callus formation, and improved mechanical properties, indicate that FWA (10% w/w) is a potential intervention for delayed healing, especially in osteoporotic fractures.
Authors
- Ashish Kumar Tripathi (ORCID: https://orcid.org/0000-0002-0976-8476)
- Shikha Verma (ORCID: https://orcid.org/0000-0001-7966-9871)
- Divya Rai (ORCID: https://orcid.org/0000-0002-4610-0088)
- Anirban Sardar (ORCID: https://orcid.org/0000-0002-7840-1862)
- Prabhat Ranjan Mishra (ORCID: https://orcid.org/0000-0002-7418-8283)
- Ritu Trivedi (ORCID: https://orcid.org/0000-0002-9524-2541)
- Nikhil Rai
- Lal Hingorani (ORCID: https://orcid.org/0000-0003-0371-0633)
- Anupama Yadav (ORCID: https://orcid.org/0000-0002-8438-0658)
- Geeta Dhaniya
- Kunal Chutani (ORCID: https://orcid.org/0000-0003-4994-6289)
- Anuj Raj
- Bhaskar Maji
Institutions
- Jawaharlal Nehru University (IN)
- Central Drug Research Institute (IN)
- Directorate of Medicinal and Aromatic Plants Research (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fendo.2025.1540237
- Citations
- 4
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 9.53