Bacteriophage therapy created the necessary conditions for successful antibiotic suppression in a periprosthetic hip joint infection: a Case Report
The administration of bacteriophages may be a valuable, less-invasive adjunct therapy to successfully suppress PJI. Bacteriophage selection, preparation and administration, however, remains associated with administrative obstacles, greatly limiting availability and practicability. Nevertheless, research and developments in this domain should be pursued, particularly considering issues with future antibiotic limitations and cost associated with treatment failure in PJI.
Authors
- Michel Schläppi (ORCID: https://orcid.org/0000-0002-0278-6276)
- Lorenz Leitner (ORCID: https://orcid.org/0000-0001-5764-3494)
- Shawna E. McCallin (ORCID: https://orcid.org/0000-0002-4277-7753)
- İlker Uçkay (ORCID: https://orcid.org/0000-0002-5552-0973)
- B A Fritz
- Sarah Djebara
- Peter M. Wahl (ORCID: https://orcid.org/0000-0002-8895-8621)
- Archana Loganathan (ORCID: https://orcid.org/0000-0003-4770-9060)
- Sandro Hodel (ORCID: https://orcid.org/0000-0003-1521-2527)
- Jens Scheidegger
Institutions
- University of Bern (CH)
- University of Zurich (CH)
- Kantonsspital Winterthur (CH)
- University Hospital of Zurich (CH)
- Queen Astrid Military Hospital (BE)
- Universitätsklinik Balgrist (CH)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fmed.2025.1564369
- Citations
- 5
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Universität Zürich
- Swiss Continence Foundation
- Continence Foundation of Australia