Pre-existing adipose tissue signaling profile related to obesity determines disease outcome of COVID-19: addressing obesity should be a priority for future pandemic preparedness
Given the significant link demonstrated between leptin dysregulation in obesity and mortal severity of COVID-19, addressing obesity should be a priority therapeutic target in terms of future pandemic preparedness. Mechanistic studies are recommended to further elucidate the importance of metabolic vs immune modulation by resistin in COVID-19, to identify future therapeutic targets.
Authors
- Martin Kidd (ORCID: https://orcid.org/0000-0002-4887-7296)
- Graeme Meintjes (ORCID: https://orcid.org/0000-0003-1196-4414)
- Coenraad F.N. Koegelenberg (ORCID: https://orcid.org/0000-0002-5563-8429)
- Arifa Parker (ORCID: https://orcid.org/0000-0002-2005-698X)
- Nadiya Ahmed (ORCID: https://orcid.org/0000-0002-3916-5027)
- Candice Snyders (ORCID: https://orcid.org/0000-0002-8571-6029)
- Jantjie Taljaard (ORCID: https://orcid.org/0000-0002-5210-9054)
- Kelly Petersen-Ross (ORCID: https://orcid.org/0000-0003-2887-6568)
- Léanie Kleynhans (ORCID: https://orcid.org/0000-0003-1635-253X)
- Tongai Maponga (ORCID: https://orcid.org/0000-0002-6876-3712)
- Carine Smith (ORCID: https://orcid.org/0000-0001-5924-9204)
- Shubhangi R. Parkar
Institutions
- South African Medical Research Council (ZA)
- University of Cape Town (ZA)
- Stellenbosch University (ZA)
- Groote Schuur Hospital (ZA)
- Tygerberg Hospital (ZA)
- Mater Research (AU)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
- National Research Foundation (ZA)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fendo.2025.1506065
- Citations
- 1
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Wellcome Trust
- National Research Foundation