<scp>PARP</scp> Inhibitors Rechallenge in Patients With Recurrent Ovarian Cancer: A Multicentre Real‐World Study in China

PARPi rechallenge as maintenance therapy may be feasible and tolerable. Achieving CR after the last chemotherapy is associated with longer PFS and combined therapies may improve outcomes, indicating potential to overcome PARPi resistance.

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Publication Details

Journal
BJOG An International Journal of Obstetrics & Gynaecology
Published
2025-04-24
DOI
https://doi.org/10.1111/1471-0528.18181
Primary Topic
PARP inhibition in cancer therapy
Type
article
Field-Weighted Citation Impact
0.00
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article

PARP Inhibitors Rechallenge in Patients With Recurrent Ovarian Cancer: A Multicentre Real‐World Study in China

Guorong Yao, Jianxiao Zheng, Jinghui Hu, Fei Zheng et al.
BJOG An International Journal of Obstetrics & Gynaecology
PARP inhibition in cancer therapy
article

PARP Inhibitors Rechallenge in Patients With Recurrent Ovarian Cancer: A Multicentre Real‐World Study in China

Guorong Yao, Jianxiao Zheng, Jinghui Hu, Fei Zheng, Enchun Li, Lingjun Zhao, Jie Liu, Feng Shao, Shan Pan, Jin Li, Hua Zhu, X. Wu, Wei Zhou
article en

Abstract

PARPi rechallenge as maintenance therapy may be feasible and tolerable. Achieving CR after the last chemotherapy is associated with longer PFS and combined therapies may improve outcomes, indicating potential to overcome PARPi resistance.

BJOG An International Journal of Obstetrics & GynaecologyVol. 132(S4)
Shanghai Medical College of Fudan University (CN), Wenzhou Medical University (CN), First Affiliated Hospital of Wenzhou Medical University (CN), Fudan University Shanghai Cancer Center (CN), Zhejiang Cancer Hospital (CN), Ningbo No. 2 Hospital (CN), Huzhou Central Hospital (CN), Women's Hospital, School of Medicine, Zhejiang University (CN), Zhejiang Taizhou Hospital (CN), Yueqing People's Hospital (CN), University of Chinese Academy of Sciences (CN), First Affiliated Hospital Zhejiang University (CN)
Good health and well-being
Openalex Percentile: Top 87%
PARP inhibition in cancer therapy
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