The miR-941/FOXN4/TGF-β feedback loop induces N2 polarization of neutrophils and enhances tumor progression of lung adenocarcinoma
In summary, these findings reveal the key role of N2-TANs and the miR-941/FOXN4/TGF-β signaling loop in LUAD progression and provide potential therapeutic targets for future interventions.
Authors
- Xianying Zhang (ORCID: https://orcid.org/0000-0001-5740-2199)
- Xiaojing Zhang (ORCID: https://orcid.org/0000-0003-1189-5420)
- Baoyi Zhu (ORCID: https://orcid.org/0000-0002-6727-3607)
- Zisheng Chen
- Junwei Gao (ORCID: https://orcid.org/0000-0003-1944-144X)
- Ling Lai
- Peibin Lin (ORCID: https://orcid.org/0009-0001-4146-9441)
- Xitong Huang
- Dongbo Tian
- Dazhong Yin (ORCID: https://orcid.org/0000-0002-6481-640X)
- Zhanfang Kang (ORCID: https://orcid.org/0000-0001-7010-8701)
Institutions
- China Pharmaceutical University (CN)
- Xiyuan Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1561081
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.75