In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy
The therapeutic potential of 1,8-bis(phenylsulfonyl)-1,8-dihydropyrrolo [2,3-b] indole in epilepsy <i>via</i> Klotho modulation was observed. Targeting metabolic, inflammatory, and apoptotic pathways presents a promising strategy for epilepsy management. Further research is required to optimize clinical translation and ensure long-term efficacy and safety.
Authors
- Mohd Ashif Khan (ORCID: https://orcid.org/0000-0003-1576-8779)
- Maria Noorani
- Divya Vohora (ORCID: https://orcid.org/0000-0003-1852-9191)
- Mansi Dahalia
- Haya Majid (ORCID: https://orcid.org/0000-0003-1439-1172)
- Imran A. Khan (ORCID: https://orcid.org/0000-0002-2014-4277)
- Nidhi Agarwal (ORCID: https://orcid.org/0000-0002-2509-3026)
- Akshat Rathi
- M. J. Khan
- Sayeed Ur Rehman
- Mohammed Samim
Institutions
- Jamia Hamdard (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fphar.2025.1580943
- Citations
- 4
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.72
Funders
- Indian Council of Medical Research