Elevated thiamine level is associated with activating interaction between HIF-1α and SLC19A3 in experimental myopic guinea pigs

The current study suggests that the choroidal tissue in myopic eyes is hypoxic and has metabolic abnormalities. Thiamine, a critical molecule for metabolism, may play a significant role in the process. Our findings indicate that changes in thiamine levels within the choroidal tissue are associated with elevated choroidal HIF-1α and activation of SLC19A3, which enhances thiamine transport. This suggests an adaptive regulatory mechanism for thiamine in myopia. Our research highlights thiamine as a potential target for pharmacological inhibitors and could lead to new insights into the study of the molecular mechanisms of myopia, as well as novel strategies for treating the disease.