Therapeutic effects of medicinal and food-based traditional herbal couples on type 2 diabetes mellitus based on pharmacodynamics and pharmacokinetics
The results indicated that CR-PLR can stimulate intestinal flora, increase the content of SCFAs, activate intestinal GPR43 protein, and promote the secretion of GLP-1 in intestinal L cells, which plays a therapeutic role in the treatment of T2DM. Additionally, cytology and pharmacokinetics experiments have proved that cinnamic acid (CA) can enhance the absorption and transport of puerarin (PUR) by inhibiting the efflux effects mediated by P-gp and MRP efflux transporters. The present study exhibites the scientific and reasonable menaning of this novel Chinese herb couple treating T2DM from the perspecives of pharmacodynamics and pharmacokinetics.
Authors
- Deling Wu (ORCID: https://orcid.org/0000-0001-6027-0625)
- Yuhang Xu
- Mengyao Cui
- Xiaoqin Chu (ORCID: https://orcid.org/0000-0002-6899-3796)
- Xiaoliang Li (ORCID: https://orcid.org/0000-0001-5448-7318)
- Jing Li (ORCID: https://orcid.org/0000-0002-0013-9139)
- Hongyan Zhai
Institutions
- University of Science and Technology of China (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Bozhou People's Hospital (CN)
- Anhui Transport Consulting & Design Institute (China) (CN)
- ZheJiang Institute For Food and Drug Control (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-25
- DOI
- https://doi.org/10.3389/fphar.2025.1560271
- Citations
- 3
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.67